Alzeimer’s has become a major threat: Rangappa

“Alzheimer’s, cancer, diabetes mellitus, inflammation, cardio vascular diseases are the major health complications that are threatening the world today,” said Vice Chancellor of University of Mysore (UoM), Prof K S Rangappa.

He was speaking at the centenary lecture organised by the (UoM) as part of the centenary celebrations in the city on Friday. Delivering a lecture on topic ‘Alzheimer’s disease and cancer: An old-age disease with an age-old solution’, Rangappa said, “Alzheimer’s disease is a progressive neurodegenerative disorder that starts in the mid 40s or 50s where the first symptoms show impaired memory followed by impaired thoughts and speech, ending in complete helplessness. The Alzheimer’s diseases disrupt travelling of electrical charges and the activity of neurotransmitters and leads to nerve cell death and tissue loss throughout the brain. Over a period of time, the brain shrinks dramatically affecting all its functions. Biochemists have investigated that protein misfolding and tanopathy are the main biochemical characteristics of Alzheimer’s disease.”

“Today most of the drugs consist of a chemical entity called heterocycles. These heterocyclic systems occur in variety of natural and synthetic compounds that are essential to life in various ways. They have always been attracting the attention of scientists working both in natural products and synthetic organic compounds. The major strategies to treat the diseases are by activation of M1-receptio by agonist and inhibition of acetylcholine esterase,” he added.

Later, he shared his experience in investigating and dealing with drugs to cure the Alzheimer’s diseases and cancer.

Emeritus professor at IISC, Prof K J Rao, UoM Registrar Rajanna and others were present.


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